Acetyl-l-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury
نویسندگان
چکیده
منابع مشابه
Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury.
In the present study, we evaluated the therapeutic efficacy of acetyl-l-carnitine (ALC) administration on mitochondrial dysfunction following tenth thoracic level contusion spinal cord injury (SCI) in rats. Initial results from experiments in vitro with naïve mitochondria showed that, in the absence of pyruvate, ALC can be used as an alternative substrate for mitochondrial respiration. Addition...
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Acetyl-l-carnitine (ALC) facilitates the entry and exit of fatty acids from mitochondria and plays an essential role in energy metabolism. Although ALC is known to exert neuroprotective effects in multiple neurological diseases, its effects on spinal cord injury (SCI)-induced mitochondrial impairments and apoptosis remain unclear. In this study, we aimed to evaluate the putative effects of ALC ...
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Following the initial acute stage of spinal cord injury, a cascade of cellular and inflammatory responses will lead to progressive secondary damage of the nerve tissue surrounding the primary injury site. The degeneration is manifested by loss of neurons and glial cells, demyelination and cyst formation. Injury to the mammalian spinal cord results in nearly complete failure of the severed axons...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2010
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2010.06764.x